Department of Zoology

University of Delhi,India


Madan Mohan Chaturvedi, Professor


Epigenetics and Chromatin Biology Laboratory

We focus on purification and characterization of a novel SWI/SNF family of ATP-dependent chromatin remodeler from chicken liver. We have found a novel H3-specific protease that specifically cleaves N-terminal portion of histone H3, thereby removes epigenetic marks on it. We have established a model of liver regeneration in mouse, to study epigenetic regulation of regeneration process. Using an inflammatory model system in mouse, we study changes in oscillatory response of the key inflammatory transcription factor, NF-B.

Umesh Rai, Professor


Reproductive Physiology Laboratory

Our research is focused on comparative immuno-endocrinology and reproductive physiology, using both in-vivo and in-vitro approaches. We also investigate cell-cell interactions in the testis, Leydig cell activities by Sertoli cells, mast cells and testicular macrophages. In ectotherm vertebrates, we are working on endocrine and paracrine regulation of testicular immune responses. We also work fish: immunoregulatory role of hypothalamo-hypophsial-adrenocortical axis, symathoadrenomedullary system, pineal gland and endogenous opioid peptides.

Rina Chakrabarti, Professor


Nutritional Physiology Laboratory

We work on nutritional physiology of carp larvae. We evaluate digestive enzyme profiles in carps during ontogenic development, and carry out purification and characterization of proteases (trypsin and chymotrypsin) in digestive system of Indian major carps. Our research interests extends to the development of aquaculture techniques for fish and fish feed, e.g. zooplankton, and the role of zooplankton in larviculture. We have designed an eco-friendly recirculating system using a combination of biological filter and hydroponic system.

Neeta Sehgal, Professor


Fish Biology Laboratory

Our studies have established that estrogens regulate the synthesis of vitellogenin and choriogenin in the liver. We have (i) shown the expression of Vg (A and B) and ER (α and β) genes in response to estrogenic compounds, (ii) developed specific and highly sensitive ELISA for detection of vitellogenin and choriogenin in fish blood, and (iii) standardized techniques for isolation of viable hepatocytes, and used them in in-vitro investigation of metabolism and biosynthetic activities in liver cells. Our current focus is on the mechanism of egg hardening, that is essential for successful embryogenesis and hatching of viable young fishes.

Vinod Kumar, Professor


Chronobiology Laboratory

Our research centers on understanding the mechanisms by which daily clocks and yearly calendars control temporal organization of behaviours, physiology and life history in song birds. We focus on: (i) to demonstrate the involvement of biological clocks in pre-migratory and migratory behaviours, (ii) changes in the brain (neurogenesis/ synaptogenesis) in response to seasons and life history stage, (iii) endocrinology of seasonal behaviours, and (iv) gene and protein expression in relation to changes in the life history status.

Rakesh Kumar Seth, Professor


Applied Entomology and Radiation Biology Laboratory

We are involved in developing an environmentally safe biorational pest management strategy using nuclear techniques in radio-genetic methods and augmentation of biological control, with continuous support of IAEA. ‘Inherited Sterility Technique’ (a modified SIT) using sub-sterilizing gamma doses is established for the suppression of a serious tropical pest, Spodopteralitura. Studies on use of radiation as phyto-sanitary treatment, radiation biology of mosquitoes and Sf9 (a highly radio-resistant insect cell line) as a eukaryoticmodel, and radiation hormesis are in progress.

Dileep Kumar Singh,Professor


Toxicology Laboratory

My laboratory works on pesticide residue analysis and microbial biodiversity and ecology of soil from different regions and condition. We focus on isolation and identification of unexplored free living nitrogen fixing bacteria, and have isolated nif H gene from unculturable bacteria, a nitrogen metabolizing bacteria with role in nitrogen fixation. We also work on endosulfan degradation, and have isolated microbes Bordetella sp. B9, Pseudomonas aeruginosa S9 and Pseudomonas aeruginosa S2, which can quickly degrade endosulfan.

Rita Singh,Professor


Reproductive Biology Laboratory

Our current research focus is on the identification of disease susceptibility genes in granulosa cells of human PCOS patients with and without Insulin resistance”. We also look into the “signaling mechanism involved in the regulation of glucose metabaolism in granulosa cells by FSH and LH”. Another major area we focus on is “Proteomics of human Plasma from Lung, Breast and Ovarian cancer Patients for discovering Cancer Biomarkers.

Shibnath Mazumder,Professor


Immunobiology Laboratory

We are trying to understand the pathogenicity of A. hydrophila using both fish and mouse model. We have identified the role of virulence plasmid in the pathogenicity and suggested mechanisms by which the bacterium induces host cell apoptosis. We also work on the mechanisms of arsenic toxicity and are currently engaged in studying the signal transduction pathways induced by arsenic with aim of using this information to induce apoptosis of cancer cell, especially of chemo-resistant variety.

Anju Shrivastava,Professor


Cell Signaling and Molecular Immunology Laboratory

We have three major research interests. (i) To understand the biology of macrophages and dendritic cells (DCs) under stress conditions, and the regulatory mechanisms in signal transduction during interaction of macrophages/DC cells with other cells of the immune system. (ii) To assess the regulation of signaling mechanism involved in tumorigenesis and tumor progression. (iii) Nanomedicine: Developing nanoparticles as novel carrier and adjuvant for DNA Vaccine and for effective enzyme-prodrug therapy wherein the benign prodrug can be converted in functional drug at the targeted site.

Sharmila Basu Modak,Professor


Molecular Genetics Laboratory

My main research area is Molecular genetics of the heme degrading enzyme Heme oxygenase-1 (Hmox1). We are studying the role of this gene during development using the Hmox1 gene-targeted mouse model. We have characterized the phenotype of the mutation in the Hmox1-knockout mouse embryos and found a developmental delay in the kidneys. From the results obtained it appears the Hmox2, the constitutive isoform of Hmox, is not compensating for Hmox1 in the KO embryos. Our current research is directed towards deciphering the effects of Hmox1 deficiency on heme metabolism and iron transport.

Rajagopal Raman,Professor


Gut Biology Laboratory

We use insects as a model to understand the role of gut microbial community in their hosts. Using Helicoverpaarmigera and Bemisiatabaci, we aim to study the gut microbial structure and the functional role played by these microbes in the insect’s growth and development. We propose that understanding the microbial diversity in insect guts and their critical roles in insect growth and development will offer crucial information for designing future pest management strategies.

Mallikarjun Shakarad,Professor


Evolutionary Biology Laboratory

Our laboratory aims to understand the dynamics of life-history trait associations in Drosophila melanogaster through simultaneous selection on two traits that are shown to be negatively genetically correlated. There has been positive selection response for the two divergent traits, for more than 100 generations now. Through comparative studies of these selected and their unselected ancestral populations, we aim to provide a better understanding to the fine print associated with evolution of life-history traits using various experimental approaches.

Namita Agrawal,Professor


Fly Laboratory

We aim to understand the mechanisms of late onset neurodegeneration in human with particular focus on the polyglutamine diseases including Huntington’s Disease. We have humanized flies (Drosophila) by inserting mutant human disease genes such as the Huntington’s gene into flies. Using the transgenic fly model, which mimics the disease symptoms, we are trying to understand the mechanisms of neurodegeneration and also identify therapeutic strategies with least side effect for the treatment of these devastating disease.

Yogendra Singh,Professor


Bacterial Pathogenesis Laboratory

We aim to study the bacterial pathogenesis which include the mechanism of infection as well as the mechanism by which disease develops. So we focus our study on bacterial protein toxins and the signal transduction pathway in bacteria during pathogenesis.

Alok C. Bharti,Professor


Molecular Oncology Laboratory

We focus on molecular oncology in order to investigate the chemistry of cancer. We work on transcriptional regulation in cancer stem cell biology, tumor immunology and also aim to investigate the host-virus interaction. We apply this study to find out molecular diagnostic tools in oncology.

R.K. Negi, Professor


Fish Molecular Biology

We work on aquatic biodiversity wherein we focus on fish genomics and metagenomics. We aim to study gut microbiome of fishes in order to investigate the influence of environmental and host factors on the establishment of the bacterial populations and the importance of these microbial communities on host health, development and nutrition.

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Department of Zoology

University of Delhi

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